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KMID : 0381120150370020161
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Genes and Genomics
2015 Volume.37 No. 2 p.161 ~ p.171
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Evolutional and functional analysis of four microRNAs derived from transposable elements
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Kim Yun-Ji
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Abstract
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Transposable elements (TEs) are interspersed in the host genomic regions, and induce various effects to the host. Recent study shows TE sequences can provide microRNA (miRNA) sequences which have a crucial role in the organisms by silencing target mRNAs. In this study, 14 TE-derived miRNAs were identified by overlapping >50 % with expressed sequence tag. Among them, miR-330, miR-648, miR-1254, and miR-1825 were examined regarding their expression patterns and evolutionary conservation in various species. MiR-330 and miR-648 were highly expressed in the bone marrow and cerebellum tissues, while miR-1825 showed high expression in the fetal liver tissue. Additionally, MiR-1254 showed dominant expression in the skeletal muscle. These TE-derived miRNAs showed an inhibitory effect on the expression of their target genes, MLL2 and ARHGEF12. These findings confirmed that TEs play important roles to regulate gene expression by providing miRNA sequences and they may contribute to the evolution of biological complexity in human genome.
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KEYWORD
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Transposable elements, TE-derived miRNA, Inhibition of target gene, Evolutionary conservation
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